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DHEA

Description

DHEA is a hormone produced in the adrenal glands. DHEA levels reach their peak in early adulthood and decline as we age. By age 60, DHEA is at approximately 5-15% of what it was in early adulthood.

Signs and Symptoms for Nutrient Applications

- Adrenal support - Lupus - Erectile dysfunction - Osteoporosis in postmenopausal women - Autoimmune diseases - Depression - Performance enhancement

Clinical Applications/Research

DHEA

The adrenal glands secrete androgens called dehydroepiandrosterone (DHEA) and androstenedione (which can metabolize to testosterone or estradiol), and also glucocorticoids, the major one being cortisol. During adrenal stress, the ratio of cortisol to DHEA will be extremely high. In fact, this ratio can be used as a lab value to determine adrenal stress. DHEA concentration is thought to reflect vitality, and is sometimes called the “anti-aging” hormone. Deepak Chopra notes a correlation of DHEA and youthful properties, and also notes that people who meditate seem to have higher levels of this substance circulating in their blood. DHEA has been used as a supplement because of some of these correlations and suggested properties, however it should be cautioned that DHEA is a steroid hormone, and that it can be metabolized to testosterone/estradiol. DHEA supplementation needs should be determined by a functional laboratory test before a perscription is given. As research is compiled on hormones that are used as supplements, sometimes long-term effects are not seen until extensive research is done. In support of this theory, evidence is now accumulating to show that DHEA supplementation is correlated with increased PSA (prostate specific antigen) in men with a high risk for prostate cancer. A natural approach to maintaining healthy DHEA levels without supplementing with a hormone is to build the strength of the adrenal glands. Reducing stress levels relieves stress on the adrenal glands, and allows for proper ratios of cortisol to DHEA. If natural therapies do not work and laboratory tests indicate need for supplementation, then DHEA can be used.

Suggested Dosage

5-25 mg per day for women or 10-50 mg per day for men or as directed by your healthcare professional.

Contraindications/Toxicology

Only people with low blood levels of DHEA should take this hormone (<130 mg/dL in women, <180 mg/dL in men). High dose DHEA (100-200 mg) does have negative sides effects including hepatotoxicity, masculinization side effects in women or excessive aggressiveness in males. High dose DHEA may be administered in automimmune diseases, such as lupus. DHEA is not recommended for people under 40, unless blood levels are low. The International Olympic Committee and National Football League has banned this substance due to its anabolic steroid effects.

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

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