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Pyridoxal-5-Phosphate

Description

Vitamin B-6, or pyridoxine, is involved in many reactions such as amino acid synthesis into protein and the production of hydrochloric acid in the stomach. It is a food supplement used often by premenstrual women.

Signs and Symptoms for Nutrient Applications

Wide variety of symptoms including: - Muscle weakness - Nervousness - Depression - Irritabillity - Dermatitis - Cracks at the corner of the mouth - Glossitis (smoothness of tongue) - Visual disturbances - Morning sickness - Amino acid/ protein abnormalities

Clinical Applications/Research

P-5-P

Although vitamin B-6 has three natural forms (pyridoxine, pyridoxamine, and pyridoxal), the phosphorylated form of pyridoxine, pyridoxal-5-phosphate (P-5-P), functions as the active coenzyme in a wide variety of functions. For instance, it is essential in amino acid metabolism; supports production of gamma-aminobutyric acid (GABA) (which is important in central nervous system function); aids in antibody and red blood cell production and also DNA and RNA synthesis; is important in fluid balance regulation (sodium/potassium balance); is necessary for the synthesis of brain neurotransmitters, inhibits the formation of homocysteine (a major risk factor in arteriosclerosis) and helps maintain normal intracellular levels of magnesium. There is a high requirement during pregnancy for hormonal and fluid balance maintenance.

Suggested Dosage

50 mg daily or as directed by your healthcare professional.

Contraindications/Toxicology

B-6 should not be taken in amounts greater than 250 mg, because neurological problems have been known to result (Murray M. ibid p. 475). Shils and Young estimate the amounts causing peripheral neuropathy to be 2-6 grams per day (2000-6000 mg) (Shils & Young. Modern Nutrition of Health and Disease. Lea and Farbiger, Phil. PA 1988). Shils and Young add that, "Ingestion of moderate excesses of vitamin B-6 appears to be without ill effect, although it has been reported that a B-6 dependency is induced in normal human adults given a supplement of 200 mg of pyridoxine for each of 33 consecutive days (Shils & Young, ibid). Medicinal amounts of any vitamin, mineral or specialty nutrient should only be taken with the advice of a trained licensed healthcare professional.

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

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