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Selenium

Description

In addition to being a cofactor for numerous enzymes, selenium is an antioxidant which has received a lot of attention for its reported role in contributing to a healthy immune defense. Selenium is one of the minerals that is increasingly harder to find in foods as our soils get depleted of this natural nutrient.

Signs and Symptoms for Nutrient Applications

- Premature aging - Cancer risk reduction - Heart disorders - Cataracts - Inflammatory conditions - Immune deficiency - Environmental allergies - Liver injury - Heavy metal toxicity - Thyroid support - Possible infertility - Congenital abnormalities may be related to crib death

Clinical Applications/Research

Selenium

Selenium functions as an antioxidant. Aside from having antioxidant properties of its own, it is an essential part of glutathione peroxidase enzyme (an antioxidant enzyme), necessary for prostaglandin production, thyroid hormone activation and preserves the elasticity of tissues by delaying oxidation of polyunsaturated fatty acids. Selenium, as part of the glutathione peroxidase enzyme, is involved with antioxidant reactions. Additionally, however, it has reported antioxidant activity of its own, the mechanism of which is not certain (Shils & Young, Modern Nutrition in Health and Disease 1988. Lea and Farbiger. Phil. Pa. p. 263). Studies on the metabolism of phenobarbitol in rats suggest that selenium is needed for normal functioning of the hepatic microsomal P-450 system, and this function is also independent of glutathione peroxidase. Epidemiological studies suggest that many diseases, such as heart disease and cancer, are higher in areas where selenium is depleted in the soil. For instance, cultivating garlic and onion in selenium reduced total tumor yield up to 75%, with garlic being more powerful than onion in cancer inhibition. This study in Carcinogenesis suggests that the high-selenium garlic/onion is an ideal food form for cancer prevention (Carcinogenesis 1994;15(9):1881-5). Qidong County in China is a high-risk area for hepatoma, and this has been correlated to low levels of selenium in the soil and in the plasma of residents (Prev Med 1993;22(5):712-22). Administration of selenium is reported to inhibit the incidence of hepatoma (Prev Med ibid).

Suggested Dosage

200-400 mcg daily or as directed by your healthcare professional.

Contraindications/Toxicology

High amounts of selenium (1,000 mcg per day) negatively affect the nervous system and demonstrate toxicity symptoms including depression, vomiting, nervousness and hair and fingernail loss. Medicinal amounts of any vitamin, mineral or specialty nutrient should only be taken with the advice of a trained licensed healthcare professional.

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

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